“We observed a statistically significant synergism between different doses of MEN1112/OBT357 and 5-Azacytidine and Decitabine on a number of AML cell lines,” said Monica Binaschi, PhD, Director of the Preclinical and Translational Oncology Department of Menarini Ricerche. “These results seem to confirm the immune-modulatory role of 5-Azacytidine and Decitabine, which may increase the sensitivity of leukemic cells to MEN1112/OBT357. These new findings suggest that pretreatment with these two agents could promote and enhance tumor cell killing activity by MEN1112/OBT357, and provide a strong rationale for evaluating these combinations in clinical trial.” (e�?i��, i��e�� 2018e�� 9i�� 11i?? 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